DNAL1

Across TCGA pan-cancer cohorts, DNAL1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of DNAL1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where DNAL1 RNA is repressed in tumor relative to normal tissue. In most cancer types DNAL1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where DNAL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.511	<.001	11	view →
THCA	Male	III,IV	−1.434	<.001	11	view →
KIRC	Male	III,IV	−0.553	<.001	11	view →
LUSC	Female	II,III,IV	−1.057	<.001	8	view →
LIHC	Female	All	+0.433	<.001	8	view →
LUAD	Female	II,III,IV	−0.583	<.001	7	view →
CHOL	Male	All	+1.873	<.001	5	view →
ESCA	Male	All	+0.694	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

DNAL1–KICH

Open the KICH breakdown →