DNAJC5B

Across TCGA pan-cancer cohorts, DNAJC5B Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DNAJC5B data layer compared with 24 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher DNAJC5B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DNAJC5B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, LUAD, and UCEC are the cancer types where DNAJC5B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.234	0.809	.003	16	view →
LUAD	OS	Median	III,IV	0.057	0.680	<.001	12	view →
UCEC	DFS	Median	All	1.000	0.629	.031	10	view →
GBM	DFS	Median	All	0.052	0.242	.011	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DNAJC5B–COAD (OS)

Open the COAD breakdown →