DNAJC5B

Across TCGA pan-cancer cohorts, DNAJC5B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DNAJC5B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DNAJC5B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DNAJC5B is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, LUSC, and LUAD are the cancer types where DNAJC5B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAJC5B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.299	<.001	12	view →
LUSC	Male	II,III,IV	−1.532	<.001	8	view →
LUAD	Female	II,III,IV	−1.154	<.001	8	view →
THCA	All	IV	+0.527	.002	8	view →
KIRP	Male	All	+1.171	<.001	7	view →
STAD	All	II,III,IV	+0.650	<.001	7	view →
BRCA	Female	II,III,IV	+0.534	<.001	6	view →
ESCA	All	II,III,IV	+0.524	.036	4	view →
BLCA	All	All	+0.333	.041	2	view →
READ	All	III,IV	−0.295	.018	2	view →
UCEC	All	All	+0.225	.015	2	view →
PRAD	All	All	+0.164	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DNAJC5B–KIRC

Open the KIRC breakdown →