DNAJC5B

Across TCGA patient cohorts, DNAJC5B mutation is significantly associated with the RNA expression of many other genes, with 492 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC5B-associated genes across cancer lineages are PMS2P1, ITGAE, and RNA5SP424. Each is linked with DNAJC5B in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC5B-to-partner and partner-to-DNAJC5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PMS2P1 grouped by DNAJC5B-low versus DNAJC5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC5B→partner) and Y-score (partner→DNAJC5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PMS2P1 →	+0.530	+2.617	.008	.006	3	2
UCEC	ITGAE →	+0.445	+3.700	.004	.001	3	2
HNSC	RNA5SP424 →	+0.310	+6.468	<.001	.001	3	2
SKCM	PDXP →	+0.548	+3.214	.005	<.001	3	2
SKCM	MYO19 →	+0.472	+3.497	<.001	.002	3	2
UCEC	CRYBB2P1 →	+0.564	+2.606	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 492 associations by consensus.

PMS2P1 by DNAJC5B expression — UCEC

Explore this box plot interactively →