DNAJC5B

Across TCGA patient cohorts, DNAJC5B mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC5B-associated genes across cancer lineages are 4E-BP1, 14-3-3_beta, and PI3K-p85. Each is linked with DNAJC5B in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC5B-to-partner and partner-to-DNAJC5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by DNAJC5B-low versus DNAJC5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC5B→partner) and Y-score (partner→DNAJC5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.309	+2.837	.029	.035	3	2
SKCM	14-3-3_beta →	-0.173	-3.000	.003	.035	3	1
SKCM	PI3K-p85 →	+0.215	+3.182	.027	.009	3	1
SKCM	CD31 →	-0.152	-2.983	.040	.034	3	1
UCEC	A-Raf_pS299 →	-0.241	-3.169	<.001	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.195	-3.321	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

4E-BP1 by DNAJC5B expression — UCEC

Explore this box plot interactively →