DNAJC5

Across TCGA patient cohorts, DNAJC5 mutation is significantly associated with the RNA expression of many other genes, with 273 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC5-associated genes across cancer lineages are RNU6-458P, OR7E18P, and RNU1-17P. Each is linked with DNAJC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC5-to-partner and partner-to-DNAJC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-458P grouped by DNAJC5-low versus DNAJC5-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC5→partner) and Y-score (partner→DNAJC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	RNU6-458P →	+0.328	+7.939	<.001	.008	3	1
CESC	OR7E18P →	+0.065	+6.342	<.001	.001	3	1
CESC	RNU1-17P →	+0.378	+5.103	<.001	.008	3	1
CESC	RNU6-1066P →	+0.344	+5.418	.002	.005	3	1
CESC	RNA5SP198 →	+0.411	+6.144	<.001	.001	3	1
CESC	LINC00457 →	+0.058	+5.201	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 273 associations by consensus.

RNU6-458P by DNAJC5 expression — PRAD

Explore this box plot interactively →