DNAJC28

Across TCGA patient cohorts, DNAJC28 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC28-associated genes across cancer lineages are JNK2, C-Raf, and EGFR_pY1068. Each is linked with DNAJC28 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC28-to-partner and partner-to-DNAJC28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by DNAJC28-low versus DNAJC28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC28→partner) and Y-score (partner→DNAJC28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.174	+2.222	.039	.011	3	2
UCEC	C-Raf →	+0.146	+2.321	.016	.034	3	2
UCEC	EGFR_pY1068 →	-0.336	-4.000	.001	<.001	3	1
UCEC	ER-alpha_pS118 →	-0.318	-2.700	.037	.006	3	1
UCEC	A-Raf_pS299 →	-0.131	-3.321	.009	.010	3	1
UCEC	FOXO3a →	-0.096	-3.156	.025	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

JNK2 by DNAJC28 expression — UCEC

Explore this box plot interactively →