DNAJC25

Across TCGA pan-cancer cohorts, DNAJC25 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DNAJC25 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DNAJC25 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNAJC25 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where DNAJC25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.357	0.914	<.001	39	view →
PDAC	DFS	Tertile	All	0.346	0.635	.005	10	view →
HNSC	DFS	Quartile	All	0.802	0.470	.008	10	view →
OV	DFS	Quartile	All	0.430	0.884	.045	8	view →
LUAD	DFS	Quartile	All	0.929	0.801	.021	6	view →
GBM	OS	Median	All	0.708	0.815	.048	1	view →
LSCC	OS	Median	II,III,IV	0.682	0.877	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DNAJC25–CCRCC (DFS)

Open the CCRCC breakdown →