DNAJC25

Across TCGA pan-cancer cohorts, DNAJC25 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DNAJC25’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DNAJC25 RNA is repressed in tumor relative to normal tissue. In most cancer types DNAJC25 is over-expressed in tumor, although a few such as THCA and LIHC show the opposite, repressed pattern.

THCA, LIHC, and HNSC are the cancer types where DNAJC25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAJC25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−0.979	<.001	9	view →
LIHC	Female	II,III,IV	−0.879	<.001	8	view →
HNSC	All	IV	+0.528	<.001	8	view →
STAD	All	II,III,IV	+0.595	<.001	7	view →
KIRC	Male	All	−0.329	<.001	6	view →
LUSC	Male	All	+0.325	<.001	4	view →
CHOL	All	All	−1.158	<.001	3	view →
LUAD	All	All	+0.178	.003	3	view →
UCEC	All	IV	−1.250	.003	2	view →
ESCA	All	All	+0.765	.001	2	view →
KIRP	All	All	−0.374	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DNAJC25–THCA

Open the THCA breakdown →