DNAJC25

Across TCGA patient cohorts, DNAJC25 mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC25-associated genes across cancer lineages are EIF4A2P5, RNA5SP408, and RNU7-128P. Each is linked with DNAJC25 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC25-to-partner and partner-to-DNAJC25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF4A2P5 grouped by DNAJC25-low versus DNAJC25-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC25→partner) and Y-score (partner→DNAJC25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	EIF4A2P5 →	+0.135	+5.517	.003	<.001	3	2
UCEC	RNA5SP408 →	+0.344	+3.186	.007	.008	3	2
UCEC	RNU7-128P →	+0.775	+3.315	<.001	.001	3	2
UCEC	MIR6512 →	+0.803	+3.239	<.001	.001	3	1
UCEC	RN7SL726P →	+0.192	+3.167	.001	.003	3	1
UCEC	RNA5SP414 →	+0.944	+3.577	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

EIF4A2P5 by DNAJC25 expression — LUSC

Explore this box plot interactively →