DNAJC2

Across TCGA patient cohorts, DNAJC2 mutation is significantly associated with the RNA expression of many other genes, with 4,616 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC2-associated genes across cancer lineages are MIR4659A, RNU6-525P, and OR56A4. Each is linked with DNAJC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNAJC2-to-partner and partner-to-DNAJC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4659A grouped by DNAJC2-low versus DNAJC2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC2→partner) and Y-score (partner→DNAJC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR4659A →	+0.675	+4.346	<.001	.007	3	3
STAD	RNU6-525P →	+1.159	+4.035	<.001	.004	3	3
HNSC	OR56A4 →	+0.045	+5.182	.003	.001	3	2
HNSC	RNA5SP197 →	+0.528	+4.372	<.001	.007	3	2
HNSC	RNU6-1305P →	+0.406	+4.912	<.001	.005	3	2
HNSC	RNU6ATAC15P →	+0.294	+5.008	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,616 associations by consensus.

MIR4659A by DNAJC2 expression — HNSC

Explore this box plot interactively →