DNAJC18

Across TCGA patient cohorts, DNAJC18 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC18-associated genes across cancer lineages are STAT5a, Caspase-8, and MEK1. Each is linked with DNAJC18 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC18-to-partner and partner-to-DNAJC18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT5a grouped by DNAJC18-low versus DNAJC18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC18→partner) and Y-score (partner→DNAJC18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT5a →	+0.526	+3.000	.022	.037	3	1
UCEC	Caspase-8 →	-0.326	-2.973	.024	.035	3	1
UCEC	MEK1 →	+0.535	+3.000	.011	.037	2	1
UCEC	Cyclin-B1 →	+0.737	+3.000	.023	.037	2	1
UCEC	Di-Ras3 →	-0.185	-3.000	.031	.037	1	2
UCEC	p62 Lck ligand →	+0.473	+3.000	.011	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

STAT5a by DNAJC18 expression — UCEC

Explore this box plot interactively →