DNAJC18

Across TCGA pan-cancer cohorts, DNAJC18 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated DNAJC18 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher DNAJC18 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNAJC18 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KICH, KIRC, and LUSC are the cancer types where DNAJC18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	II,III,IV	0.551	0.961	<.001	85	view →
KIRC	DFS	Median	All	0.708	0.556	<.001	82	view →
LUSC	DFS	Tertile	III,IV	0.217	0.535	.004	45	view →
BRCA	OS	Median	III,IV	0.902	0.752	<.001	38	view →
LGG	DFS	Tertile	All	0.528	0.264	<.001	33	view →
DLBC	OS	Median	II,III,IV	0.744	1.000	.013	29	view →
LIHC	OS	Tertile	All	0.613	0.744	.008	24	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
HNSC	OS	Quartile	All	0.590	0.865	.002	23	view →
UCEC	OS	Quartile	All	0.585	0.799	.003	22	view →
PAAD	DFS	Tertile	All	0.399	0.227	.006	17	view →
COAD	OS	Median	IV	0.864	0.403	.005	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

DNAJC18–KICH (DFS)

Open the KICH breakdown →