DNAJC11

Across TCGA patient cohorts, DNAJC11 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC11-associated genes across cancer lineages are MEK1, A-Raf_pS299, and FoxM1. Each is linked with DNAJC11 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC11-to-partner and partner-to-DNAJC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by DNAJC11-low versus DNAJC11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC11→partner) and Y-score (partner→DNAJC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MEK1 →	+0.302	+3.025	.003	.019	3	2
UCEC	A-Raf_pS299 →	-0.149	-2.222	<.001	.009	3	2
UCEC	FoxM1 →	+0.178	+1.874	.040	.049	3	2
UCEC	INPP4B →	-0.276	-2.807	.010	.002	3	2
UCEC	MSH2 →	-0.256	-1.558	<.001	.032	3	2
UCEC	p62 Lck ligand →	+0.298	+3.700	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

MEK1 by DNAJC11 expression — COAD

Explore this box plot interactively →