DNAJB8

Across TCGA patient cohorts, DNAJB8 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJB8-associated genes across cancer lineages are TFRC, ATM, and Caspase-7-cleavedD198. Each is linked with DNAJB8 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJB8-to-partner and partner-to-DNAJB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by DNAJB8-low versus DNAJB8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB8→partner) and Y-score (partner→DNAJB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.530	+2.222	.018	.011	3	2
UCEC	ATM →	-0.812	-4.000	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.632	+2.341	.012	.019	3	2
COAD	Cyclin-D1 →	+0.149	+3.178	.020	.010	3	1
UCEC	ER-alpha_pS118 →	-0.332	-2.222	.029	.011	3	1
UCEC	ERK2 →	+0.169	+2.222	.038	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

TFRC by DNAJB8 expression — UCEC

Explore this box plot interactively →