DNAJB8

Across TCGA cell cohorts, DNAJB8 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,019 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible DNAJB8-associated GO terms across cancer lineages are Microtubule polymerization or depolymerization, Regulation of axon extension, and Regulation of chromosome organization. Each is linked with DNAJB8 in more than 6 cancer types. Because this analysis shows association rather than direction, both DNAJB8-to-partner and partner-to-DNAJB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule polymerization or depolymerization grouped by DNAJB8-low versus DNAJB8-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB8→partner) and Y-score (partner→DNAJB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Microtubule polymerization or depolymerization →	+0.082	+0.040	<.001	.005	3	7
LUNG_SCLC	Regulation of axon extension →	+0.059	+0.030	.004	.007	3	6
BREAST	Regulation of chromosome organization →	+0.047	+0.018	.003	.007	3	6
LUNG_SCLC	Response to dehydroepiandrosterone →	+0.123	+0.037	<.001	<.001	3	6
LUNG_SCLC	Negative regulation of DNA-templated transcription initiation →	+0.071	+0.031	.005	.004	3	6
LUNG_SCLC	Negative regulation of transcription initiation by RNA polymerase II →	+0.071	+0.031	.005	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,019 associations by consensus.

Microtubule polymerization or depolymerization by DNAJB8 expression — LUNG_SCLC

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