DNAJB5

Across TCGA patient cohorts, DNAJB5 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJB5-associated genes across cancer lineages are ATM, EGFR_pY1068, and JNK2. Each is linked with DNAJB5 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNAJB5-to-partner and partner-to-DNAJB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DNAJB5-low versus DNAJB5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB5→partner) and Y-score (partner→DNAJB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.515	-2.459	.005	.019	3	3
UCEC	EGFR_pY1068 →	-0.213	-2.321	.040	.006	3	1
UCEC	JNK2 →	+0.241	+1.884	.003	.030	3	1
UCEC	Ku80 →	+0.278	+1.820	.004	.016	3	1
UCEC	Notch1 →	+0.189	+2.472	.001	.010	3	1
UCEC	p27_pT198 →	+0.100	+1.807	.024	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ATM by DNAJB5 expression — UCEC

Explore this box plot interactively →