DNAJB5

Across TCGA pan-cancer cohorts, DNAJB5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DNAJB5’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where DNAJB5 RNA is repressed in tumor relative to normal tissue. In most cancer types DNAJB5 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and KICH are the cancer types where DNAJB5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAJB5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−3.897	<.001	11	view →
COAD	Male	II,III,IV	−1.694	<.001	11	view →
KICH	All	III,IV	−1.827	<.001	10	view →
HNSC	All	III,IV	+1.113	<.001	10	view →
LIHC	Female	II,III,IV	+1.054	<.001	9	view →
STAD	Female	All	−2.664	<.001	5	view →
THCA	All	All	+0.470	<.001	5	view →
BRCA	Female	All	−0.181	.024	4	view →
READ	All	All	−1.982	.006	2	view →
UCEC	All	All	−1.424	<.001	2	view →
PRAD	All	All	−1.214	<.001	2	view →
CHOL	All	All	+0.823	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DNAJB5–BLCA

Open the BLCA breakdown →