DNAJB5

Across TCGA cell cohorts, DNAJB5 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAJB5-associated genes across cancer lineages are OR2M5, TMEM244, and CD300H. Each is linked with DNAJB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJB5-to-partner and partner-to-DNAJB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M5 grouped by DNAJB5-low versus DNAJB5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB5→partner) and Y-score (partner→DNAJB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2M5 →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TMEM244 →	+0.515	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.039	+4.415	<.001	.007	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	OR10A3 →	+0.041	+5.539	<.001	.003	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR2M5 by DNAJB5 expression — LARGE_INTESTINE

Explore this box plot interactively →