DNAJB4

Across TCGA patient cohorts, DNAJB4 mutation is significantly associated with the RNA expression of many other genes, with 2,181 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJB4-associated genes across cancer lineages are RNU6-1246P, RNU6ATAC41P, and IGHD5-12. Each is linked with DNAJB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJB4-to-partner and partner-to-DNAJB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1246P grouped by DNAJB4-low versus DNAJB4-high in KIRC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB4→partner) and Y-score (partner→DNAJB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	RNU6-1246P →	+0.307	+5.680	<.001	.001	3	2
KIRC	RNU6ATAC41P →	+0.350	+4.652	.001	.007	3	2
UCEC	IGHD5-12 →	+0.425	+2.953	<.001	.002	3	2
UCEC	RPL23AP4 →	+0.097	+2.302	<.001	.002	3	2
BRCA	PRYP5 →	+0.116	+8.057	<.001	.005	3	2
UCEC	YTHDF3-AS1 →	+0.725	+2.223	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,181 associations by consensus.

RNU6-1246P by DNAJB4 expression — KIRC

Explore this box plot interactively →