DNAJB2

Across TCGA patient cohorts, DNAJB2 mutation is significantly associated with the RNA expression of many other genes, with 415 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJB2-associated genes across cancer lineages are PRAMEF13, MIR6515, and HMGB3P18. Each is linked with DNAJB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJB2-to-partner and partner-to-DNAJB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF13 grouped by DNAJB2-low versus DNAJB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB2→partner) and Y-score (partner→DNAJB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAMEF13 →	+0.022	+3.132	<.001	.005	3	2
BRCA	MIR6515 →	+0.717	+8.055	<.001	.007	3	1
BLCA	HMGB3P18 →	+0.101	+4.289	<.001	.007	3	1
BLCA	RNU2-42P →	+0.294	+3.628	.001	.006	3	1
BLCA	OR52M2P →	+0.031	+4.814	<.001	.003	3	1
BLCA	MTND4P27 →	+0.038	+3.792	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 415 associations by consensus.

PRAMEF13 by DNAJB2 expression — UCEC

Explore this box plot interactively →