DNAJA3

Across TCGA patient cohorts, DNAJA3 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJA3-associated genes across cancer lineages are p90 RSK, ATM, and Cyclin-B1. Each is linked with DNAJA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJA3-to-partner and partner-to-DNAJA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by DNAJA3-low versus DNAJA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJA3→partner) and Y-score (partner→DNAJA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.183	+2.331	.017	.019	3	2
UCEC	ATM →	-0.449	-1.906	.013	.016	3	2
UCEC	Cyclin-B1 →	+0.560	+1.906	.013	.016	3	2
UCEC	14-3-3_beta →	-0.089	-2.295	.028	.033	3	1
UCEC	eIF4E →	+0.199	+1.906	.019	.016	3	1
UCEC	JNK_pT183_Y185 →	-0.168	-2.000	.013	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

p90 RSK by DNAJA3 expression — UCEC

Explore this box plot interactively →