DNAJA3

Across TCGA pan-cancer cohorts, DNAJA3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DNAJA3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DNAJA3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DNAJA3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

COAD, KIRP, and LUAD are the cancer types where DNAJA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAJA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.096	<.001	11	view →
KIRP	All	II,III,IV	+0.704	<.001	10	view →
LUAD	All	III,IV	+0.654	<.001	9	view →
STAD	Male	II,III,IV	+0.808	<.001	8	view →
LUSC	Male	All	+0.857	<.001	7	view →
HNSC	All	II,III,IV	+0.393	<.001	7	view →
BRCA	All	II,III,IV	+0.691	<.001	6	view →
LIHC	All	All	+0.383	<.001	6	view →
CHOL	All	All	+0.731	<.001	5	view →
THCA	Male	III,IV	−0.305	.009	5	view →
ESCA	All	II,III,IV	+0.799	.019	2	view →
READ	Female	All	+0.660	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DNAJA3–COAD

Open the COAD breakdown →