DNAI4

Across TCGA patient cohorts, DNAI4 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAI4-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PCNA, and eIF4E. Each is linked with DNAI4 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNAI4-to-partner and partner-to-DNAI4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by DNAI4-low versus DNAI4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAI4→partner) and Y-score (partner→DNAI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.413	-2.070	.002	.001	3	3
UCEC	PCNA →	+0.257	+2.050	<.001	<.001	3	3
UCEC	eIF4E →	+0.215	+1.807	<.001	<.001	3	2
UCEC	GAPDH →	+0.391	+1.906	.014	.014	3	2
UCEC	PKC-delta_pS664 →	-0.083	-1.382	.021	.017	3	2
UCEC	Rictor_pT1135 →	-0.070	-1.765	.021	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

p38-MAPK_pT180_Y182 by DNAI4 expression — UCEC

Explore this box plot interactively →