DNAI4

Across TCGA pan-cancer cohorts, DNAI4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DNAI4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where DNAI4 RNA is repressed in tumor relative to normal tissue. In most cancer types DNAI4 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and THCA are the cancer types where DNAI4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAI4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.762	<.001	11	view →
COAD	Male	IV	−2.076	<.001	11	view →
THCA	Male	III,IV	−1.062	<.001	11	view →
KIRC	Male	III,IV	−0.771	<.001	9	view →
LUSC	Female	II,III,IV	−1.775	<.001	8	view →
READ	All	II,III,IV	−1.482	<.001	6	view →
LUAD	Female	II,III,IV	−1.065	<.001	6	view →
STAD	All	All	+0.408	<.001	5	view →
CHOL	Male	All	+1.540	<.001	3	view →
KIRP	All	III,IV	−0.379	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DNAI4–KICH

Open the KICH breakdown →