DNAI4

Across TCGA cell cohorts, DNAI4 mutation is significantly associated with the RNA expression of many other genes, with 259 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAI4-associated genes across cancer lineages are AVP, SLC32A1, and H2BW2. Each is linked with DNAI4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAI4-to-partner and partner-to-DNAI4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by DNAI4-low versus DNAI4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAI4→partner) and Y-score (partner→DNAI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	AVP →	+0.046	+5.781	<.001	.001	3	2
BLOOD_Leukemia	SLC32A1 →	+0.485	+2.638	<.001	.009	3	1
BLOOD_Leukemia	H2BW2 →	+0.054	+2.971	.004	.003	3	1
BLOOD_Leukemia	GZMK →	+0.425	+2.774	<.001	.006	3	1
BLOOD_Leukemia	C9 →	+0.826	+2.807	<.001	.008	3	1
BLOOD_Leukemia	TNNT2 →	+0.280	+3.523	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 259 associations by consensus.

AVP by DNAI4 expression — BREAST

Explore this box plot interactively →