DNAI4

Across TCGA cell cohorts, DNAI4 mutation is significantly associated with the mutation status of many other genes, with 4,054 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAI4-associated genes across cancer lineages are PANX2, RHAG, and CASZ1. Each is linked with DNAI4 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNAI4-to-partner and partner-to-DNAI4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PANX2 grouped by DNAI4-low versus DNAI4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAI4→partner) and Y-score (partner→DNAI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PANX2 →	+5.297	+5.297	.004	.004	1	3
LUNG_NSCLC_LUAD	RHAG →	+5.772	+5.772	.002	.002	1	3
SKIN	CASZ1 →	+2.772	+3.662	.002	.002	1	3
LUNG_NSCLC_LUAD	FAP →	+4.187	+5.000	.008	.008	1	3
STOMACH	SMARCD3 →	+4.807	+4.807	.008	.008	1	3
LUNG_NSCLC_LUAD	ULK2 →	+5.772	+5.772	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,054 associations by consensus.

PANX2 by DNAI4 expression — BREAST

Explore this box plot interactively →