DNAI2

Across TCGA patient cohorts, DNAI2 mutation is significantly associated with the RNA expression of many other genes, with 3,715 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAI2-associated genes across cancer lineages are C15orf61, PBK, and RRM2. Each is linked with DNAI2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DNAI2-to-partner and partner-to-DNAI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C15orf61 grouped by DNAI2-low versus DNAI2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAI2→partner) and Y-score (partner→DNAI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C15orf61 →	+0.370	+2.534	<.001	<.001	3	4
COAD	PBK →	+0.889	+2.847	<.001	.001	3	4
UCEC	RRM2 →	+0.701	+2.523	<.001	<.001	3	4
BRCA	RNU6-1018P →	+0.461	+6.639	<.001	.001	3	3
COAD	PTP4A3 →	-1.161	-2.807	<.001	.003	2	4
COAD	CDCA2 →	+0.765	+2.820	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,715 associations by consensus.

C15orf61 by DNAI2 expression — UCEC

Explore this box plot interactively →