DNAI1

Across TCGA pan-cancer cohorts, DNAI1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DNAI1 data layer compared with 20 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher DNAI1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DNAI1 expression acts as an unfavorable survival marker.

CESC, READ, and CHOL are the cancer types where DNAI1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.121	0.829	<.001	36	view →
READ	OS	Median	II,III,IV	0.290	0.847	<.001	19	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SKCM	DFS	Median	III,IV	0.087	0.647	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DNAI1–CESC (OS)

Open the CESC breakdown →