DNAI1

Across TCGA patient cohorts, DNAI1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAI1-associated genes across cancer lineages are Rb, Cyclin-B1, and eIF4E. Each is linked with DNAI1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNAI1-to-partner and partner-to-DNAI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rb grouped by DNAI1-low versus DNAI1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAI1→partner) and Y-score (partner→DNAI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Rb →	-0.185	-2.000	.009	.031	3	2
SKCM	Cyclin-B1 →	+0.559	+3.597	.002	.001	2	3
UCEC	eIF4E →	+0.135	+1.678	.048	.021	3	2
UCEC	Ku80 →	+0.231	+2.013	.002	<.001	3	2
UCEC	MEK1 →	+0.410	+2.000	<.001	<.001	3	2
UCEC	MSH2 →	-0.188	-2.196	.012	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Rb by DNAI1 expression — SKCM

Explore this box plot interactively →