DNAH8

Across TCGA patient cohorts, DNAH8 mutation is significantly associated with the RNA expression of many other genes, with 9,227 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAH8-associated genes across cancer lineages are MRPS18C, RCC1, and GRSF1. Each is linked with DNAH8 in more than 6 cancer types. Because this analysis shows association rather than direction, both DNAH8-to-partner and partner-to-DNAH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS18C grouped by DNAH8-low versus DNAH8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH8→partner) and Y-score (partner→DNAH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS18C →	+0.303	+1.294	<.001	<.001	3	7
STAD	RCC1 →	+0.538	+2.108	<.001	<.001	3	7
STAD	GRSF1 →	+0.380	+1.794	<.001	.001	3	6
STAD	CENPE →	+0.703	+2.824	<.001	.001	3	6
UCEC	NOC2L →	+0.225	+1.221	.009	<.001	3	6
UCEC	C1orf174 →	+0.334	+1.458	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,227 associations by consensus.

MRPS18C by DNAH8 expression — UCEC

Explore this box plot interactively →