DNAH8

Across TCGA cell cohorts, DNAH8 mutation is significantly associated with the RNA expression of many other genes, with 939 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAH8-associated genes across cancer lineages are ZNF214, ACTRT1, and ENOPH1. Each is linked with DNAH8 in more than 3 cancer types. Because this analysis shows association rather than direction, both DNAH8-to-partner and partner-to-DNAH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF214 grouped by DNAH8-low versus DNAH8-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH8→partner) and Y-score (partner→DNAH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNF214 →	-0.572	-2.548	.001	.006	3	4
PANCREAS	ACTRT1 →	+0.009	+2.817	.001	.009	3	3
SKIN	ENOPH1 →	+0.351	+2.700	.003	.001	3	3
LUNG_NSCLC_LUAD	ZNF584 →	-0.555	-3.321	.001	.004	3	3
LARGE_INTESTINE	TYW3 →	+0.514	+1.584	.003	.005	3	3
BLOOD_Lymphoma	FAM183A →	+0.159	+2.064	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 939 associations by consensus.

ZNF214 by DNAH8 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →