DNAH6

Across TCGA patient cohorts, DNAH6 mutation is significantly associated with the RNA expression of many other genes, with 7,779 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAH6-associated genes across cancer lineages are RNU6-1285P, SENP3-EIF4A1, and CHUK. Each is linked with DNAH6 in more than 3 cancer types. Because this analysis shows association rather than direction, both DNAH6-to-partner and partner-to-DNAH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1285P grouped by DNAH6-low versus DNAH6-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH6→partner) and Y-score (partner→DNAH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNU6-1285P →	+0.252	+2.429	.001	.001	3	4
SKCM	SENP3-EIF4A1 →	+0.144	+2.650	.009	.005	3	4
UCEC	CHUK →	+0.351	+1.784	<.001	<.001	3	4
UCEC	SLC25A11 →	+0.272	+1.235	<.001	<.001	3	4
UCEC	PCCB →	+0.398	+2.001	<.001	<.001	3	4
UCEC	TTL →	+0.334	+1.192	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,779 associations by consensus.

RNU6-1285P by DNAH6 expression — LIHC

Explore this box plot interactively →