DNAH3

Across TCGA patient cohorts, DNAH3 mutation is significantly associated with the RNA expression of many other genes, with 10,792 significant associations in total. COAD shows the largest number of these associations.

The most reproducible DNAH3-associated genes across cancer lineages are ASF1B, CEP55, and SKA1. Each is linked with DNAH3 in more than 6 cancer types. Because this analysis shows association rather than direction, both DNAH3-to-partner and partner-to-DNAH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASF1B grouped by DNAH3-low versus DNAH3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH3→partner) and Y-score (partner→DNAH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASF1B →	+0.640	+2.099	<.001	<.001	3	7
LUAD	CEP55 →	+0.769	+1.857	<.001	<.001	3	7
COAD	SKA1 →	+0.833	+2.820	<.001	<.001	3	7
LUAD	CDKN3 →	+0.648	+1.834	.001	.002	3	6
LUAD	NCAPG →	+0.716	+1.952	<.001	.002	3	6
COAD	MRPS15 →	+0.279	+1.598	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,792 associations by consensus.

ASF1B by DNAH3 expression — LUAD

Explore this box plot interactively →