DNAH3

Across TCGA pan-cancer cohorts, DNAH3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DNAH3’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where DNAH3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DNAH3 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

STAD, KIRP, and BLCA are the cancer types where DNAH3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAH3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Male	All	+0.379	<.001	8	view →
KIRP	All	II,III,IV	+0.351	<.001	7	view →
BLCA	All	All	+0.306	.006	7	view →
KIRC	All	All	+0.068	.001	7	view →
LUSC	All	All	−0.611	.001	5	view →
KICH	Male	All	−0.049	<.001	5	view →
HNSC	Male	All	+0.257	.007	4	view →
BRCA	Female	All	+0.124	.001	4	view →
LIHC	Female	All	+0.078	.022	3	view →
ESCA	All	II,III,IV	+0.635	.011	2	view →
LUAD	All	IV	+0.530	.006	2	view →
PAAD	All	All	+0.442	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DNAH3–STAD

Open the STAD breakdown →