DNAH3

Across TCGA patient cohorts, DNAH3 mutation is significantly associated with the total protein of many other genes, with 110 significant associations in total. COAD shows the largest number of these associations.

The most reproducible DNAH3-associated genes across cancer lineages are Caspase-7-cleavedD198, TFRC, and PCNA. Each is linked with DNAH3 in more than 6 cancer types. Because this analysis shows association rather than direction, both DNAH3-to-partner and partner-to-DNAH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DNAH3-low versus DNAH3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH3→partner) and Y-score (partner→DNAH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.613	+2.815	<.001	<.001	3	7
STAD	TFRC →	+0.411	+3.169	.040	.017	3	7
LUAD	PCNA →	+0.145	+3.700	.008	.001	3	5
STAD	4E-BP1 →	+0.300	+2.321	.001	.004	3	5
LUAD	Cyclin-B1 →	+0.629	+1.807	<.001	.004	3	4
COAD	EGFR_pY1068 →	-0.376	-2.662	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

Caspase-7-cleavedD198 by DNAH3 expression — COAD

Explore this box plot interactively →