DNAH3

Across TCGA cell cohorts, DNAH3 mutation is significantly associated with the RNA expression of many other genes, with 1,837 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAH3-associated genes across cancer lineages are NR3C2, CENPS, and DDX3X. Each is linked with DNAH3 in more than 3 cancer types. Because this analysis shows association rather than direction, both DNAH3-to-partner and partner-to-DNAH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NR3C2 grouped by DNAH3-low versus DNAH3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH3→partner) and Y-score (partner→DNAH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NR3C2 →	+0.765	+2.700	<.001	.001	3	4
LARGE_INTESTINE	CENPS →	+0.486	+2.584	.002	.002	3	4
LUNG_NSCLC_LUAD	DDX3X →	+0.417	+3.459	.009	.002	3	3
LARGE_INTESTINE	ERI1 →	+0.627	+3.321	<.001	.002	3	3
LARGE_INTESTINE	ZBED3 →	+0.720	+2.000	.001	.009	3	3
LARGE_INTESTINE	C1QBP →	+0.667	+1.977	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,837 associations by consensus.

NR3C2 by DNAH3 expression — LARGE_INTESTINE

Explore this box plot interactively →