DNAH17-AS1

Across TCGA pan-cancer cohorts, DNAH17-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DNAH17-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DNAH17-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DNAH17-AS1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, COAD, and UCEC are the cancer types where DNAH17-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAH17-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.424	<.001	12	view →
COAD	Male	II,III,IV	+0.239	<.001	10	view →
UCEC	All	IV	+0.165	.004	6	view →
LUSC	Male	All	+0.316	<.001	5	view →
LUAD	All	All	+0.190	<.001	5	view →
READ	Female	All	+0.130	<.001	5	view →
BRCA	Female	All	+0.070	<.001	4	view →
STAD	Male	II,III,IV	+0.144	.037	3	view →
KICH	All	All	−0.038	.002	3	view →
CHOL	All	All	+0.290	.015	2	view →
BLCA	All	All	+0.223	.016	2	view →
LIHC	All	II,III,IV	+0.013	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DNAH17-AS1–HNSC

Open the HNSC breakdown →