DNAH1

Across TCGA pan-cancer cohorts, DNAH1 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated DNAH1 data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DNAH1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DNAH1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and UCEC show a favorable association.

KIRP, THYM, and BRCA are the cancer types where DNAH1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.556	0.897	<.001	26	view →
THYM	OS	Median	All	0.186	0.931	<.001	15	view →
BRCA	OS	Median	III,IV	0.153	0.837	<.001	14	view →
PAAD	OS	Median	All	0.011	0.641	<.001	12	view →
BLCA	OS	Median	III,IV	0.200	0.592	.004	12	view →
LUSC	DFS	Median	All	1.000	0.634	.019	10	view →
LIHC	OS	Median	III,IV	0.270	0.732	.021	9	view →
UCEC	DFS	Median	II,III,IV	0.811	0.417	.016	8	view →
THCA	DFS	Median	II,III,IV	0.136	0.764	.008	6	view →
LUAD	OS	Median	III,IV	0.185	0.689	<.001	6	view →
LGG	DFS	Median	All	0.499	0.829	.011	4	view →
ACC	OS	Median	All	0.149	0.686	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

DNAH1–KIRP (OS)

Open the KIRP breakdown →