DNAAF4

Across TCGA patient cohorts, DNAAF4 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAAF4-associated genes across cancer lineages are PCNA, 14-3-3_beta, and EGFR_pY1068. Each is linked with DNAAF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAAF4-to-partner and partner-to-DNAAF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by DNAAF4-low versus DNAAF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAAF4→partner) and Y-score (partner→DNAAF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.233	+1.584	.006	.036	3	2
UCEC	14-3-3_beta →	-0.098	-1.571	.012	.036	3	1
UCEC	EGFR_pY1068 →	-0.240	-2.000	.014	.010	3	1
UCEC	eIF4G →	+0.274	+2.000	.024	.010	3	1
UCEC	FASN →	+0.337	+3.459	.029	.005	2	2
UCEC	Heregulin →	-0.098	-2.000	.044	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PCNA by DNAAF4 expression — UCEC

Explore this box plot interactively →