DNAAF4

Across TCGA pan-cancer cohorts, DNAAF4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DNAAF4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where DNAAF4 RNA is repressed in tumor relative to normal tissue. In most cancer types DNAAF4 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LUSC are the cancer types where DNAAF4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAAF4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.481	<.001	11	view →
THCA	Male	All	−0.661	<.001	9	view →
LUSC	All	III,IV	−1.106	<.001	8	view →
STAD	All	II,III,IV	+0.465	<.001	8	view →
BLCA	Male	All	+0.518	.001	7	view →
COAD	Female	II,III,IV	+0.402	<.001	7	view →
LUAD	All	All	−0.425	<.001	6	view →
BRCA	All	All	+0.354	<.001	6	view →
CHOL	Male	All	+1.356	<.001	5	view →
READ	Male	All	+0.893	.021	5	view →
LIHC	Male	II,III,IV	+0.114	.005	5	view →
ESCA	All	II,III,IV	+1.245	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DNAAF4–KICH

Open the KICH breakdown →