DNAAF4

Across TCGA cell cohorts, DNAAF4 mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAAF4-associated genes across cancer lineages are Savolitinib, Quizartinib, and GSK2110183B. Each is linked with DNAAF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAAF4-to-partner and partner-to-DNAAF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Savolitinib grouped by DNAAF4-low versus DNAAF4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAAF4→partner) and Y-score (partner→DNAAF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Savolitinib →	+0.415	+2.777	.020	.038	3	2
LARGE_INTESTINE	Quizartinib →	+0.382	+2.874	.011	.021	3	1
LARGE_INTESTINE	GSK2110183B →	+0.604	+2.871	.036	.021	2	1
LARGE_INTESTINE	TL-2-105 →	+0.516	+2.874	.004	.021	2	1
LARGE_INTESTINE	GSK429286A →	+0.327	+2.874	.027	.021	2	1
LARGE_INTESTINE	GSK690693 →	+0.561	+2.874	.019	.021	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Savolitinib by DNAAF4 expression — LARGE_INTESTINE

Explore this box plot interactively →