DNA2

Across TCGA patient cohorts, DNA2 protein abundance is significantly associated with the protein abundance of many other proteins, with 16,257 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DNA2-associated proteins across cancer lineages are NFIC, BIN1_T348, and AEBP1. Each is linked with DNA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNA2-to-partner and partner-to-DNA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DNA2 versus NFIC in BRCA, with a Pearson correlation of -0.55.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DNA2→partner) and Y-score (partner→DNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NFIC →	-0.681	-0.832	<.001	<.001	3	3
GBM	BIN1_T348 →	+1.275	+1.040	<.001	<.001	3	2
GBM	AEBP1 →	-0.643	-1.033	<.001	<.001	3	2
BRCA	CIT →	+0.567	+0.770	<.001	.001	3	2
HNSC	CNIH4 →	+0.559	+1.668	.003	<.001	3	2
GBM	ANG →	-0.885	-1.132	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,257 associations by consensus.

DNA2 vs NFIC — BRCA

Explore this scatter interactively →