DNA2

Across TCGA patient cohorts, DNA2 mutation is significantly associated with the RNA expression of many other genes, with 1,847 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNA2-associated genes across cancer lineages are SNRPGP7, LRRC37A13P, and RNA5SP447. Each is linked with DNA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNA2-to-partner and partner-to-DNA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPGP7 grouped by DNA2-low versus DNA2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNA2→partner) and Y-score (partner→DNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SNRPGP7 →	+0.292	+4.303	<.001	.009	3	3
LUAD	LRRC37A13P →	+0.263	+3.963	<.001	.006	3	3
SKCM	RNA5SP447 →	+0.200	+4.452	<.001	<.001	3	2
CESC	RNU6-786P →	+0.411	+3.874	<.001	.006	3	2
HNSC	BUB3P1 →	+0.095	+4.010	<.001	.006	3	2
CESC	MTND5P7 →	+0.019	+4.559	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,847 associations by consensus.

SNRPGP7 by DNA2 expression — LUAD

Explore this box plot interactively →