DMXL1

Across TCGA patient cohorts, DMXL1 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMXL1-associated genes across cancer lineages are Caspase-7-cleavedD198, MIG-6, and Transglutaminase. Each is linked with DMXL1 in more than 5 cancer types. Because this analysis shows association rather than direction, both DMXL1-to-partner and partner-to-DMXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DMXL1-low versus DMXL1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMXL1→partner) and Y-score (partner→DMXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.797	+1.882	.016	.031	3	6
BLCA	MIG-6 →	+0.102	+2.597	.023	.005	3	4
LUAD	Transglutaminase →	-0.422	-3.000	.007	.034	3	4
UCEC	PCNA →	+0.217	+1.584	<.001	<.001	3	4
SKCM	Stathmin →	+0.266	+3.610	<.001	.001	3	4
BLCA	INPP4B →	-0.547	-3.584	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

Caspase-7-cleavedD198 by DMXL1 expression — COAD

Explore this box plot interactively →