DMXL1

Across TCGA pan-cancer cohorts, DMXL1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DMXL1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DMXL1 RNA is repressed in tumor relative to normal tissue. In most cancer types DMXL1 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and LUSC are the cancer types where DMXL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DMXL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.760	<.001	8	view →
COAD	Female	All	−0.760	<.001	8	view →
LUSC	Female	All	−0.742	<.001	6	view →
LUAD	Female	II,III,IV	−0.684	<.001	6	view →
READ	Female	All	−1.136	<.001	5	view →
LIHC	All	All	+0.411	.001	5	view →
BRCA	Female	All	−0.400	<.001	4	view →
CHOL	All	All	+1.004	<.001	2	view →
UCEC	All	All	−0.687	<.001	2	view →
KIRP	Male	All	−0.618	.001	2	view →
KICH	All	All	−0.558	.004	2	view →
PRAD	All	All	+0.435	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DMXL1–THCA

Open the THCA breakdown →