DMXL1

Across TCGA cell cohorts, DMXL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,106 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DMXL1-associated GO terms across cancer lineages are Target-directed miRNA degradation, Vesicle tethering, and Golgi to endosome transport. Each is linked with DMXL1 in more than 12 cancer types. Because this analysis shows association rather than direction, both DMXL1-to-partner and partner-to-DMXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Target-directed miRNA degradation grouped by DMXL1-low versus DMXL1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DMXL1→partner) and Y-score (partner→DMXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Target-directed miRNA degradation →	+0.107	+0.600	<.001	<.001	3	13
OESOPHAGUS	Vesicle tethering →	+0.070	+0.648	.002	.001	3	13
OVARY	Golgi to endosome transport →	+0.107	+0.764	<.001	<.001	3	12
LUNG_SCLC	Regulation of centriole elongation →	+0.091	+0.643	.001	.002	3	12
LARGE_INTESTINE	Positive regulation of cilium assembly →	+0.081	+0.613	<.001	<.001	3	12
OESOPHAGUS	Nucleotide-excision repair →	+0.064	+0.728	.006	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,106 associations by consensus.

Target-directed miRNA degradation by DMXL1 expression — LUNG_SCLC

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