DMXL1

Across TCGA cell cohorts, DMXL1 mutation is significantly associated with the RNA expression of many other genes, with 1,709 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DMXL1-associated genes across cancer lineages are MAP3K10, TTC5, and NEDD1. Each is linked with DMXL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DMXL1-to-partner and partner-to-DMXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAP3K10 grouped by DMXL1-low versus DMXL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMXL1→partner) and Y-score (partner→DMXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAP3K10 →	+0.549	+1.941	.004	.009	3	3
LARGE_INTESTINE	TTC5 →	+0.612	+3.067	.001	.009	3	3
BLOOD_Leukemia	NEDD1 →	+0.629	+2.837	.004	<.001	3	3
LARGE_INTESTINE	DTWD2 →	+0.549	+1.949	.002	.002	3	3
LARGE_INTESTINE	TMEM220 →	+0.600	+2.526	<.001	.002	3	3
LARGE_INTESTINE	XRCC6 →	+0.421	+1.949	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,709 associations by consensus.

MAP3K10 by DMXL1 expression — LARGE_INTESTINE

Explore this box plot interactively →