DMRTB1

Across TCGA patient cohorts, DMRTB1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMRTB1-associated genes across cancer lineages are FoxM1, ACVRL1, and p62 Lck ligand. Each is linked with DMRTB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMRTB1-to-partner and partner-to-DMRTB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by DMRTB1-low versus DMRTB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRTB1→partner) and Y-score (partner→DMRTB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.351	+3.179	.001	.010	3	1
UCEC	ACVRL1 →	-0.166	-2.302	.005	.034	3	1
UCEC	p62 Lck ligand →	+0.506	+2.807	<.001	.003	3	1
UCEC	P-Cadherin →	-0.140	-3.169	.026	.018	3	1
UCEC	Rab25 →	-0.296	-3.169	.040	.019	3	1
UCEC	Annexin-1 →	+1.051	+3.604	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FoxM1 by DMRTB1 expression — UCEC

Explore this box plot interactively →