DMRT3

Across TCGA patient cohorts, DMRT3 RNA expression is significantly associated with the RNA expression of many other genes, with 12,156 significant associations in total. THYM shows the largest number of these associations.

The most reproducible DMRT3-associated genes across cancer lineages are DMRT1, DLX5, and PRRX2. Each is linked with DMRT3 in more than 19 cancer types. Because this analysis shows association rather than direction, both DMRT3-to-partner and partner-to-DMRT3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DMRT3 versus DMRT1 in UCEC, with a Pearson correlation of 0.66.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRT3→partner) and Y-score (partner→DMRT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DMRT1 →	+1.006	+1.369	<.001	<.001	3	20
ESCA	DLX5 →	+2.079	+1.024	<.001	<.001	3	18
ESCA	PRRX2 →	+1.389	+1.078	<.001	<.001	3	17
THYM	EGFL6 →	+1.938	+1.018	<.001	<.001	3	16
DLBC	SHOX2 →	+0.941	+0.763	<.001	<.001	3	16
THYM	PDGFRL →	+2.747	+1.216	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,156 associations by consensus.

DMRT3 vs DMRT1 — UCEC

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